贵阳市始于1965年确诊有钩体病,至今流行不断。从传染源(鼠类)和患者中只培养出黄疸群钩体。为了解健康人对该群的免疫水平与发病关系,以便今后采取合理有效的预防措施,我们于1986年作了专题调查。材料与方法一.选择市郊未接种钩体菌苗并在1985、1986年散在发生钩体病的自然村寨(稻农)为调查对象:(一)非疫区(外省、外县)者到疫区接触疫水后发病,而本寨的人未发病的村寨。(二)疫区村寨的人发病的村寨。二.对照村寨:未接种钩苗,与发病村相邻的村寨。三.对上述村寨7—60岁人群,每寨随机整群抽样50人以上,其中又随机抽175人观察流行前(1—5月)、后(11月)免疫水平消长 Guiyang City was diagnosed with leptospirosis in 1965 and has been in epidemic ever since. From the source of infection (murine) and patients only cultured jaundice ganglion. In order to understand the relationship between the level of immunity and the incidence of the healthy population in this group so that reasonable and effective preventive measures can be taken in the future, we conducted a special survey in 1986. MATERIALS AND METHODS I. The uninoculated leptospirosis vaccine in the suburbs was selected and the natural villages (rice farmers) with leptospirosis scattered in 1985 and 1986 were selected as the survey subjects: (I) Infectious areas (provinces and counties) were infected District incidence after the onset of epidemic, while the village has not affected the village. (B) of the affected villages in the incidence of the village. Two control villages: not vaccinated Hailiao, adjacent to the village and the incidence of the village. Three of the above-mentioned village of 7-60-year-olds, each walled random cluster sampling more than 50 people, of which 175 were randomized to observe the pre-epidemic (January-May), after (November) the level of immune growth