Survivin是凋亡抑制蛋白家族的一员,在抑制细胞凋亡、调控细胞周期、参与血管形成等方面发挥重要的生物学功能。Survivin在多种肿瘤组织中过量表达,与肿瘤不良预后和耐药性密切相关。Survivin作为一种潜在的肿瘤治疗靶点,其小分子抑制剂用于肿瘤治疗的研究为人们所关注。概述了Survivin的结构、功能及其在肿瘤组织中的特异性表达,综述了目前靶向Survivin的小分子抑制剂的研究进展。 Survivin, a member of the apoptosis-inhibiting protein family, plays an important biological role in inhibiting apoptosis, regulating cell cycle, and participating in angiogenesis. Survivin overexpression in a variety of tumor tissues, closely related to poor prognosis and drug resistance. Survivin as a potential target for cancer treatment, the small molecule inhibitors for the treatment of cancer is of concern. The structure, function and expression of Survivin in tumor tissue were summarized. The current research progress of small molecule inhibitors targeting Survivin was reviewed.