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目的:观察孕16～24周需终止妊娠者服用米非司酮前后UtA和UmA血流速度波型变化和胎盘微血管的改变,探讨米非司酮在引产过程中的作用环节。方法:30例对象口服米非司酮25mg,bid×3天,第4日上午加用米索前列醇200μg。服药前后检测UtA和UmA的PI、RI及S/D,并于胎盘母体面取材作电镜检查。结果:用药后UtA和UmA的PI、RI和S/D值均较用药前升高,其中UtA的RI,S/D和UmA的S/D升高值较用药前的数值差异显著(P<0.05),胎盘血管内皮细胞呈损伤性改变。结论:米非司酮能使UtA和UmA的RI和S/D值升高,导致子宫及胎盘循环受阻、缺血。
OBJECTIVE: To observe the change of blood flow velocity of UtA and UmA and the changes of placental microvessels before and after taking mifepristone in pregnant women with gestational age from 16 to 24 weeks, and to explore the role of mifepristone in induction of labor. Methods: Thirty subjects received oral mifepristone 25 mg bid twice daily for 3 days. On the morning of the 4th, misoprostol 200 μg was added. Before and after taking the medication, the PI, RI and S / D of UtA and UmA were detected and taken from the placenta mother for electron microscopy. Results: The values of PI, RI and S / D of UtA and UmA were higher than those before treatment, and the values of S / D of RI, S / D and UmA of UtA were significantly higher than those before treatment (P < 0.05), placental vascular endothelial cells showed damage. Conclusion: Mifepristone can increase the RI and S / D values of UtA and UmA, resulting in blocked uterine and placental circulation and ischemia.