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早期在自限性病毒性肝炎小鼠模型的研究中已证实,血小板可通过促进肝内的病毒特异性CD8+T细胞和病毒非特异性炎性细胞蓄积而加重急性肝损伤。基于以上观察结果,最近的一项实验通过前期建立的乙型肝炎(乙肝)病毒转基因小鼠模型(由免疫介导的慢性肝炎进展至肝细胞肝癌的模型)证实以下发现,在出现肝病后持续服用临床常规剂量的抗血小板药物(阿司匹林和氯吡格雷)可预防肝癌的发生并显
Early studies in a mouse model of self-limiting viral hepatitis have demonstrated that platelets can exacerbate acute liver injury by promoting the accumulation of virus-specific CD8 + T cells and non-specific viral cells in the liver. Based on the above observations, a recent experiment confirms the following findings through a pre-established hepatitis B (hepatitis B) virus transgenic mouse model of progression from immune-mediated chronic hepatitis to hepatocellular carcinoma, persisting in the presence of liver disease Taking a routine clinical dose of antiplatelet drugs (aspirin and clopidogrel) can prevent the occurrence of liver cancer and was