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目的:考察退热止痛散解热镇痛活性部位对明胶崩解迟缓的影响。方法:将退热止痛散解热镇痛活性部位与胶皮进行接触,以崩解值为指标,于特定时间进行测定,通过方差分析,观察两者之间是否存在交互作用。结果:以花生油为对照,退热止痛散解热镇痛活性部位与明胶接触后,出现无崩解现象,经花生油混合稀释后,明胶能崩解,但与时间和环境温度直接相关,时间越长、环境温度越高,则明胶崩解时间越长。结论:退热止痛散解热镇痛活性部位能明显影响明胶的崩解度,延长其崩解时间,在将其制备成软胶囊剂之前应对该活性部位进行包封处理。
OBJECTIVE: To investigate the effect of antipyretic analgesic and analgesic active sites on the slow disintegration of gelatin. Methods: The antipyretic analgesic and analgesic active sites were contacted with the rubber skin. The disintegration value was used as an index to measure the thermal analgesic activity at a specific time. Through the analysis of variance, the interaction between the two was observed. Results: With peanut oil as control, there was no disintegration after the thermal analgesic active site of gelatine was relieved by thermal analgesia. Gelatin disintegrated after mixing with peanut oil, but it was directly related to the time and the ambient temperature. Long, the higher the ambient temperature, the longer the gelatin disintegration time. Conclusion: The antipyretic analgesic and analgesic active sites can significantly affect the disintegration and prolong the disintegration time of gelatin, and the active site should be encapsulated before it is prepared into soft capsules.