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目的探讨天津市儿童流感样病例(ILI)呼吸道病毒病原体构成,分析ILI变化趋势以及引起ILI动态变化主要的病原。方法每周统计天津市儿童医院的流感样病例数据,并采集部分流感样病例的呼吸道标本采用多重RTPCR方法检测腺病毒(ADV)、副流感病毒(PIV)、流感病毒(Flu)、鼻病毒(RhinoV)、呼吸道合胞病毒(RSV)、人偏肺病毒(HMPV)、冠状病毒(CoV)、肠道病毒(HEV)以及博卡病毒(HBoV)。分别对流感季与非流感季每周检出的病毒病原数与ILI数据做灰色关联分析。结果呼吸道病毒的阳性检出率为56.49%,其中Flu占比最高39.15%,流感季的周ILI%变化与Flu的关联度最大(γ=0.871);非流感季与周ILI%关联度最大的是全部病毒阳性数(γ=0.884)。结论天津市儿童流感样病例中多种病毒均有检出,流感病毒仍是引起流感季ILI%变化的主要病毒病原。
Objective To investigate the constitution of respiratory virus pathogens in children with influenza-like illness (ILI) in Tianjin and analyze the change trend of ILI and the major pathogens that cause the dynamic changes of ILI. Methods The data of influenza-like cases in Tianjin Children’s Hospital were collected every week and respiratory samples of some influenza-like cases were collected. Multiple RTPCR was used to detect adenovirus (ADV), parainfluenza virus (PIV), influenza virus (Flu), rhinovirus RhinoV, RSV, HMPV, CoV, Enterovirus (HEV), and Bocavirus (HBoV). Gray relational analysis was performed on the number of virus pathogens and ILI data detected weekly in the flu season and the non-flu season respectively. Results The positive rate of respiratory virus was 56.49%, of which the highest proportion of Flu was 39.15%. The change of ILI% of Flu season was the highest (γ = 0.871), and the highest correlation of ILI% and non-flu season Is the total number of viruses positive (γ = 0.884). Conclusions A variety of viruses were detected in children with influenza-like illness in Tianjin. Influenza virus was still the major viral pathogen causing ILI% change during the flu season.