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本研究应用放射免疫法观察了心肌缺血40例血浆β内啡肽免疫活性物质(β-EP-ir)水平和可疑心肌缺血者35例运动试验前后β-EP-ir的变化。结果显示:(1)心肌缺血时血浆β-EP-ir无痛者明显高于对照组,有痛者明显低于对照组(P<0.05),各型心绞痛之间β-EP-ir无明显差异,表明β-EP-ir水平高低与心肌缺血时疼痛呈负相关。β-EP-ir升高可能是心肌缺血不引起疼痛的原因之一。(2)运动前阳性组和阴性组β-EP-ir无明显差异,运动后两组均明显升高(P<0.01),不论有无缺血型心电图表现,运动后β-EP-ir均升高,缺血与疼痛不一致,提示β-EP-ir不能作为判断运动试验后心肌缺血的指标。
In this study, we used radioimmunoassay to observe the changes of β-EP-ir before and after exercise test in 40 patients with myocardial ischemia, β-EP-ir and suspected myocardial ischemia. The results showed that: (1) The plasma levels of β-EP-ir in patients with myocardial ischemia were significantly higher than those in the control group, with pain being significantly lower than those in the control group (P <0.05); β-EP-ir Significant difference, indicating that the level of β-EP-ir and myocardial ischemia pain was negatively correlated. Elevated β-EP-ir may be one of the causes of myocardial ischemia-related pain. (2) There was no significant difference in β-EP-ir between pre-exercise and post-exercise groups, and both groups were significantly increased after exercise (P <0.01). The β-EP-ir , Ischemia and pain are inconsistent, suggesting that β-EP-ir can not be used as an indicator of myocardial ischemia after exercise test.