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非诺贝特(Fenoibrate)又名普鲁脂芬(Procetofene),化学名为2-(4-对氯苯甲酰)苯氧基-2-甲基丙酸异丙酯,是目前较为理想的降血酯药。据报道,它的药效比安妥明强,毒副作用小。关于非诺贝特的含量测定,国内上海药品标准采用水解后酸碱剩余滴定法,但此法专一性不强。本文用反相高效液相色谱法分离并用对照品鉴别,测得非诺贝特合成产品的杂质是4-氯-4-羟苯酰苯(Ⅰ)和2-(4-对氯苯甲酰)苯氧基-2-甲基丙酸(Ⅱ);以4—氯苯
Fenoibrate, also known as Procetofen, is currently known as 2- (4-p-chlorobenzoyl) phenoxy-2-methylpropionate Hypoglycemic agents. It is reported that its efficacy than clofibrate strong side effects. On the determination of fenofibrate, the domestic pharmaceutical standards in Shanghai using acid-base residual hydrolysis titration, but this method is not specific. In this paper, RP-HPLC separation and identification with the reference substance, the measured fenofibrate synthesis of impurities is 4-chloro-4-hydroxybenzoyl benzene (Ⅰ) and 2- (4-p-chlorobenzoyl ) Phenoxy-2-methylpropionic acid (II); with 4-chlorobenzene