论文部分内容阅读
本文在简要论述了喹诺酮类抗菌药的发展及光敏感性的基础上,通过研究萘啶酸的光分解性,讨论了喹诺酮的脱羧(-COOH)反应,同时涉及8-位C-F键异裂的光化学反应和质子化以及与二价阳离子形成络合物的平衡关系。利用生物模拟体系(如AOT逆胶束、水-甲醇和水-乙腈混合溶剂)对该类药物的光谱学性质进行了广泛探讨:处于激发态时的氧氟沙星和诺氟沙星的分子内电荷转移(ICT);在混合溶剂中,其荧光光谱表现出逆相溶剂化显色性;利用ICT解释了辐射速率常数和非辐射速率常数的变化;溶剂的介电效应对药物理化性质的影响大于氢键的影响并从理论上进行了解释。
In this paper, the development of quinolone antibacterials and the photosensitivity were briefly discussed. The photodegradability of nalidixic acid was discussed. The decarboxylation (-COOH) reaction of quinolones was also discussed. At the same time, Photochemical reactions and protonation and the formation of complexes with divalent cation equilibrium. The spectroscopic properties of these drugs have been extensively investigated using biological modeling systems such as AOT reverse micelles, water-methanol and water-acetonitrile mixed solvents: molecules of ofloxacin and norfloxacin in the excited state Internal charge transfer (ICT); In mixed solvents, its fluorescence spectrum showed reverse phase solvatochromism; The use of ICT explained the radiation rate constant and non-radiation rate constant changes; The dielectric effect of solvents on the physical and chemical properties of the drug The effect is greater than the hydrogen bond and is theoretically explained.