一年一度的诺贝尔化学奖备受社会关注。2004年诺贝尔化学奖分别奖给以色列科学家阿龙·切哈诺夫和阿夫拉姆·赫什科以及美国科学家欧文·罗斯,以表彰他们发现并在分子水平上认识细胞是怎样调控细胞内某些蛋白质作为靶分子,在特定时间和特定场所被分解的(这一过程被称为泛素调节蛋白水解作用)。为了帮助广大读者了解他们的科学成就,本期特刊登了陕西师范大学吴祺教授的《细胞内蛋白质是怎样被分解的——2004年诺贝尔化学奖简介》一文。 The annual Nobel Prize in chemistry is of great public concern. The 2004 Nobel Prize in Chemistry was awarded to Israeli scientists Aaron Cechanov and Avram Hershko and the American scientist Owen Rose respectively in recognition of their discovery and understanding at the molecular level how cells regulate intracellular Some proteins, as target molecules, are broken down at specific times and places (a process known as ubiquitin-mediated proteolysis). In order to help readers understand their scientific achievements, this issue featured a special article entitled “How Proteins in Cells Are Disassembled by Professor Wu Qi of Shaanxi Normal University - A Brief Introduction to the 2004 Nobel Prize in Chemistry.”