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目的:海洛因滥用导致海洛因依赖者认知控制功能损伤,本研究通过使用ERP技术来探究这种损伤在长期物质戒断后的恢复水平。方法:本研究对比参与字母Flanker任务的长期海洛因戒断组和正常组冲突适应能力的时程动态过程。结果:(1)两组被试在冲突试次上的反应时(RT_(I))均显著长于一致试次(RT_(C)),Flanker冲突效应(RT_(I-C))没有组间差异;进一步检验发现,两组被试的试次间调节的反应时之差(RT_(cI-iI))差异不显著。(2)对照组在一致-冲突试次(cI)条件下引发的N2平均振幅显著大于冲突-冲突试次条件(iI),而长期海洛因戒断组N2效应消失。(3)长期海洛因戒断组在冲动性量表上的得分显著高于对照组。结论:行为和电生理指标出现分离性的结果,即长期海洛因戒断组在反应时上能够较好的解决冲突,但是长期吸食海洛因导致其认知控制功能损伤。
OBJECTIVE: Heroin abuse causes cognitive impairment in heroin addicts. In this study, we used ERP technology to investigate the level of recovery from such damage after prolonged material withdrawal. METHODS: This study compared the time-course dynamics of conflict adaptation between long-term heroin abstinence and normal subjects involved in the letter Flanker task. Results: (1) The response time (RT_ (I)) of the two groups was significantly longer than that of the matched test (RT_ (C)). There was no difference between the two groups in the Flanker conflict effect (RT_ (IC) Further examination revealed that there was no significant difference in the response time (RT_ (cI-iI)) between the two groups during the trial run. (2) The mean amplitude of N2 induced by the control group in the concurrency-clash test (cI) was significantly greater than that of the conflict-clash test (iI), while the long-term heroin abstinence group disappeared. (3) The long-term heroin withdrawal group scored significantly higher on the impulsivity scale than the control group. CONCLUSION: The separation of behavioral and electrophysiological indicators results in that the long-term heroin abstinence group can better resolve the conflict during response, but long-term use of heroin leads to impairment of cognitive control.