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评价左旋氧氟沙星的临床有效性与安全性。采用前瞻性随机对照试验方法。试验药为左旋氧氟沙星，每次200－300mg，静脉滴注，每日2次。对照药为环丙沙星，每次200－400mg，静脉滴注，每日2次。疗程均为7－14d。结果为试验组38例与对照组35例的两组治愈率分别是76．3％与68．6％。有效率分别是97．4％与97．1％，细菌清除率分别是88．6％与89．7％。药物不良反应发生率分别是79％（3／38）与5．6％（2／36），统计学均无显著性差异。结论为左旋氧氟沙皇对于临床常见的呼吸道、泌尿道、肠道细菌感染是一种安全、有效的药物。
To evaluate the clinical efficacy and safety of levofloxacin. A prospective randomized controlled trial was used. Test drug levofloxacin, each 200-300mg, intravenous infusion, 2 times a day. Control drug ciprofloxacin, 200-400mg each time, intravenous infusion, 2 times a day. Treatment are 7-14d. The results for the experimental group 38 cases and control group 35 cases of the two groups were 76.3% cure rate and 68.6%. The effective rates were 97.4% and 97.1% respectively, and the bacterial clearance rates were 88.6% and 89.7% respectively. The incidence of adverse drug reactions were 79% (3/38) and 5.6% (2/36) respectively, with no statistically significant differences. Conclusions: Levofloxacin is a safe and effective drug for common respiratory, urinary and intestinal bacterial infections in clinic.