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研制了法莫替丁缓释片并测定其体外溶出度。结果表明：该制剂的体外溶出行为符合Ｈｉｇｕｃｈｉ方程，释药速度常数（Ｋ）主要受药物与辅料比例的影响；不同处方的释药速度常数（Ｋ）、释药５０％的时间、释药６３．２％的时间有显著差异（Ｐ＜０．０１）。
Famotidine extended release tablets were developed and their in vitro dissolution was determined. The results showed that the in vitro dissolution behavior of the preparation was in accordance with the Higuchi equation. The release rate constant (K) was mainly affected by the ratio of the drug to the excipients. The drug release rate constant (K), drug release time 50% .2% of the time was significantly different (P <0.01).