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目的探讨DPN患者颈动脉内-中膜厚度(CIMT)、颈动脉僵硬度与HbA1c的关系。方法选取T2DM组60例、DPN组100例及健康体检者(NC)60名,测定HbA1c水平、CIMT和颈动脉僵硬度。结果 DPN组HbA1c[(8.62±2.71)%vs(4.20±0.47)%,(7.59±1.98)%],CIMT[(1.01±0.11)vs(0.70±0.07),(0.81±0.09)mm]和颈动脉硬度[(827.6±123.7)vs(521.2±89.3),(629.3±113.5)]高于NC、T2DM组(P<0.05);DPN组病程高于T2DM组(P<0.05);DPN组HbA1c≥10.0%亚组CIMT[(1.11±0.09)vs(0.94±0.07),(0.73±0.06)mm]和颈动脉僵硬度[(901.5±241.5)vs(724.5±159.9),(574.1±145.3)]高于8.0%≤HbA1c<10.0%亚组和7.0%≤HbA1c<8.0%亚组(P<0.05);相关分析结果显示,HbA1c与CIMT、颈动脉僵硬度呈正相关(r=0.107、0.213,P<0.05)。结论 DPN患者CIMT、颈动脉僵硬度与HbA1c呈正相关,且HbA1c是CIMT和颈动脉僵硬度的危险因素。
Objective To investigate the relationship between carotid artery intima - media thickness (CIMT) and carotid artery stiffness and HbA1c in patients with DPN. Methods Totally 60 patients in T2DM group, 100 in DPN group and 60 in physical examination (NC) were selected for determination of HbA1c level, CIMT and carotid artery stiffness. Results In the DPN group, the ratios of HbA1c, CIMT [(8.62 ± 2.71)% vs (4.20 ± 0.47)%, (0.91 ± 0.11) vs (0.81 ± 0.09) The arterial stiffness in the DPN group was significantly higher than that in the T2DM group (P <0.05). The arterial stiffness in the DPN group was significantly higher than that in the T2DM group [(827.6 ± 123.7 vs 521.2 ± 89.3), (629.3 ± 113.5) 10.0% subgroup CIMT (1.11 ± 0.09 vs 0.94 ± 0.07, 0.73 ± 0.06) mm and carotid artery stiffness (901.5 ± 241.5 vs 724.5 ± 159.9 and 574.1 ± 145.3) The correlation analysis showed that there was a positive correlation between HbA1c and CIMT and carotid artery stiffness (r = 0.107,0.213, P <0.05) 0.05). Conclusions CIMT and carotid artery stiffness in DPN patients are positively correlated with HbA1c, and HbA1c is a risk factor for CIMT and carotid artery stiffness.