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用大佛水鼻喷雾剂治疗３０例常年性变应性鼻炎，３个月为广疗程。观察疗效，并在治疗前后测定鼻分泌物中的ＳＩｇＡ量。结果显效１８例（６０．Ｏ％），有效７例（２３．３％），无效５例（１６．７％），总有效率８３．３％。鼻分泌物中ＳＩｇＡ量比治疗前明显升高（Ｐ＜０．０１）。认为，鼻腔局部脱敏疗法的作用机理是：将变应原投用在鼻粘膜（靶器官）上，增加鼻分泌物中的ＳＩｇＡ类封闭抗体，诱发局部免疫。
Giant Buddha nasal spray treatment of 30 cases of perennial allergic rhinitis, 3 months for the wide course of treatment. The efficacy was observed and the amount of SIgA in nasal secretions measured before and after treatment. The results were effective in 18 cases (60.0%), effective in 7 cases (23.3%), ineffective in 5 cases (16.7%), the total effective rate was 83.3%. The amount of SIgA in nasal secretions was significantly higher than that before treatment (P <0.01). That nasal local desensitization mechanism of action is: the allergen cast on the nasal mucosa (target organ), increase the nasal secretions of SIgA blocking antibodies, induced local immunity.