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恶性肿瘤为严重影响人类健康的疾病之一,其病死率很高,全世界每年死于恶性肿瘤的人达数百万之众,仅排在心血管系统疾病之后。恶性肿瘤的治疗成为临床医学急迫解决的主要问题。常规治疗主要有手术治疗、化学药物治疗、放射治疗三大传统手段。化学药物治疗是以全身性治疗,通过对原发灶、转移灶和亚临床转移灶的作用,而起到治疗效果,因此化学药物治疗成为综合治疗恶性肿瘤的必不可少的治疗手段。但化疗药物因其选择性低,安全范围小,在杀灭肿瘤细胞的同时,
Malignancy is one of the diseases that seriously affect human health. Its mortality rate is so high that millions of people worldwide die of malignant tumors each year, only after cardiovascular diseases. The treatment of malignant tumors has become an urgent problem to be solved by clinical medicine. Conventional treatment mainly surgical treatment, chemical medicine, radiation therapy three traditional means. Chemotherapy is a systemic treatment that plays a therapeutic role through its effect on the primary tumor, metastases and subclinical metastases. Therefore, chemotherapy is an indispensable treatment for the comprehensive treatment of malignant tumors. However, due to its low selectivity of chemotherapy drugs, a small area of safety in the killing of tumor cells at the same time,