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糖尿病肾病(DN)是糖尿病最严重的慢性合并症之一,是导致慢性肾衰的主要病因,而炎症在其发病机制中的作用举足轻重,可通过信号通路的激活、炎症因子、细胞因子的相互作用等参与DN的发生发展。其中,p38 MAPK介导炎症在DN发生发展中的起到重要的作用。现代最新研究以p38 MAPK通路为治疗靶点,新兴的p38 MAPK抑制剂越发成为研究的热点。传统中医药在治疗DN具有独特的优势,结合中医药辨
Diabetic nephropathy (DN) is one of the most serious chronic complications of diabetes mellitus, and is the leading cause of chronic renal failure. Inflammation plays an important role in its pathogenesis and can be activated through the activation of signaling pathways, inflammatory factors, and cytokines Role in the occurrence and development of DN. Among them, p38 MAPK-mediated inflammation play an important role in the development of DN. The latest modern research to p38 MAPK pathway for the treatment of targets, the emerging p38 MAPK inhibitor has become a research hot spot. Traditional Chinese medicine in the treatment of DN has a unique advantage, combined with traditional Chinese medicine identified