论文部分内容阅读
Objective: To imastigate the effects of anisodamine on pulmonary α1- adrenergic receptor andphospholipase A, in acute lung injurg. Methods: Change of α1--adrenergic receptor (al AR ) in lung tissllesduring endotoxin--induced rat acute lung injury was measured with radioligand biding assay. The effects ofanisodamine on pulmonary α1--AR and phospholipase A2 (PLA2 ) were observed. Results: 1. 4 h after theendotoxin injection, there was a significant decrease in the maximal binding capacity of α1--AR by 34% ascompared with the control group. meanwhile elevated activity of PLA2 in rat lung and reduction of thephospholipids content of cell membrane was found. 2. Anisodamine could attenuate endotoxin--induced acutelung injury in rats. Conclusion: This effect might be related to anisodamine’s blockage of α1--AR andsuppression of PLA2, prevention of membranous phospholipids from degradation. and the reduction ofarachidonic acid release.
Objective: To imastigate the effects of anisodamine on pulmonary α1-adrenergic receptor and phospholipase A, in acute lung injurg. Methods: Change of α1 - adrenergic receptor (al AR) in lung tissllesduring endotoxin - induced rat acute lung injury was measured with radioligand Results: 1. 4 h after the endoxin injection, there was a significant decrease in the maximal binding capacity of α1 - AR by 34% ascompared with the control group. meanwhile elevated activity of PLA2 in rat lung and reduction of the phospholipids content of cell membrane was found. 2. Anisodamine could attenuate endotoxin - induced acute injury in rats. Conclusion: This effect might be related to anisodamine’s blockage of α1 - AR andsuppression of PLA2, prevention of membranous phospholipids from degradation. And the reduction of arachidonic acid release.