论文部分内容阅读
目的 研究异丙酚对家兔主动脉阻断后脊髓损害的保护作用。方法 家兔１８只，随机分为假手术组（Ａ组），缺血组（Ｂ）和异丙酚组（Ｃ）。肾下阻断腹主动脉４０ 分钟后松开。Ｃ组于阻断前静脉注射异丙酚５ｍ ｇ·ｋｇ－ １，继以２０·ｍ ｇ·ｋｇ－ １·ｈ－ １微量泵静脉输注至松开前，余２ 组则以同样方法静注等容量生理盐水作对照。测定阻断前、后及恢复后血中丙二醛（ＭＤＡ）浓度及超氧化物歧化酶（ＳＯＤ）活性，术后观察兔后肢神经功能、肌电图（ＥＭＧ）和脊髓形态学变化。结果 异丙酚明显降低血中ＭＤＡ浓度，保护ＳＯＤ活性，改善术后神经功能损害，减轻ＥＭＧ和细胞形态学改变。结论 异丙酚对家兔主动脉阻断所致的脊髓损害有良好的保护作用。
Objective To study the protective effect of propofol on spinal cord injury after aortic cross-clamping in rabbits. Methods Eighteen rabbits were randomly divided into sham operation group (A group), ischemia group (B) and propofol group (C). Under the kidney block the abdominal aorta 40 minutes after the release. In group C, propofol 5 m g · kg -1 was injected intravenously before blocking, followed by intravenous infusion of 20 · m g · kg -1 · h -1 micro-pump until the release, while the other two groups were treated with the same method Note the same volume of saline as a control. The concentrations of malondialdehyde (MDA) and superoxide dismutase (SOD) in the blood were measured before, after and after the resuscitation. The neurological function, electromyogram (EMG) and morphological changes of spinal cord were observed after operation. Results Propofol significantly decreased the level of MDA in blood, protected the activity of SOD, improved the neurological impairment, and reduced the EMG and cell morphological changes. Conclusion Propofol has a good protective effect on spinal cord injury induced by aortic cross-clamping in rabbits.