Test is one of methods to acquire human-seat pressure distribution in driving,with the deficiency of being uneasy to obtain the stress information of soft tissue inside human body and the sheer force of interface between human and seat,which can be obtained by simulation.But current simulation method focuses mainly on calculation itself other than combining it with posture prediction and cab packaging parameters,which cause it difficult to acquire accurate pressure calculation results without accurate posture of human body,and make it almost meaningless to design optimization.Therefore,a human body geometric model with posture change capability is built and linked up with Cascade Prediction Model(CPM),which takes cab packaging parameters as inputs.A detailed finite element model of driver human body is constructed and used to conduct the driver-seat interaction simulation between human body and seat.Good accordance of pressure distribution is observed between simulation and test,which validates the simulation.In addition to the distribution pattern,curves on key sections are used to analyze the pressure and shear stress on the seat surface,as well as soft tissue stress inside human body.The simulation shows that the maximum stress of buttocks locates under the ischial tuberosity,and the maximum stress of trunk occurs near the scapula posterior and the lower waist.These are the places where fatigue usually occurs.The maximum pressure of seat appears at the driver-seat contact area corresponding to the driver’s maximum skin tissue stress.In order to guide the seat design and cab packaging and study the influence of posture to pressure distribution,finite element models for different levels of cab packaging parameters are created by using CPM.The pressure distributions are calculated and their tendencies varying with cab packaging parameters are obtained.The method presented provides a new way to accurately simulate the interaction between driver human body and seat,and to guide the seat design and cab packaging so as to improve seating comfort. Test is one of methods to acquire human-seat pressure distribution in driving, with the deficiency of being uneasy to obtain the stress information of soft tissue inside human body and the sheer force of interface between human and seat, which can be obtained by simulation. But current simulation method focus mainly on calculation itself other than combining it with posture prediction and cab packaging parameters, which cause it difficult to acquire accurate pressure calculation results without accurate posture of human body, and make it almost meaningless to design optimization.Therefore, a human body geometric model with posture change capability built and linked up with Cascade Prediction Model (CPM), which takes cab packaging parameters as inputs.A detailed finite element model of driver human body is constructed and used to conduct the driver-seat interaction simulation between human body and seat. Good accordance of pressure distribution is observed between simulation and test, which validates the simulation. addition to the distribution pattern, curves on key sections are used to analyze the pressure and shear stress on the seat surface, as well as soft tissue stress inside human body. The simulation shows that the maximum stress of buttocks locates under the ischial tuberosity, and the maximum stress of trunk occurs near the scapula posterior and the lower waist. these are the places where fatigue usually occurs. the maximum pressure of seat appears at the driver-seat contact area corresponding to the driver’s maximum skin tissue stress .In order to guide the seat design and cab packaging and study the influence of posture to pressure distribution, finite element models for different levels of cab packaging parameters are created by using CPM.The pressure distributions are calculated and their tendencies varying with cab packaging parameters are obtained. The method presents provides a new way to accurately simulate the interaction between driver human body and seat, and to guide the seat design and cab packaging so as to improve seating comfort.