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目的分析奥沙利铂致结直肠癌患者过敏的危险因素。方法回顾分析185例接受奥沙利铂化疗的结直肠癌患者,分析人口学特征,既往过敏史,实验室检查,化疗方案和抗过敏预防措施的使用等。结果奥沙利铂所致过敏反应者23例,其中17例患者发生Ⅰ/Ⅱ度过敏反应,6例患者发生Ⅲ/Ⅳ度过敏反应。与无过敏反应组相比,过敏反应组患者奥沙利铂化疗间断率高,其中Ⅰ/Ⅱ度过敏反应组患者化疗次数较多。结论化疗次数增多和奥沙利铂化疗曾有间断与发生过敏反应相关。
Objective To analyze the risk factors of allergy in patients with colorectal cancer caused by oxaliplatin. Methods A retrospective analysis of 185 patients with colorectal cancer who underwent oxaliplatin chemotherapy was conducted to analyze demographic characteristics, past history of allergies, laboratory tests, chemotherapy regimens, and use of anti-allergy prophylaxis. Results Twenty-three patients were allergic to oxaliplatin, of which 17 patients had grade Ⅰ / Ⅱ allergic reaction and 6 patients had Ⅲ / Ⅳ allergic reaction. Compared with the non-allergic reaction group, the discontinuation rate of oxaliplatin chemotherapy in patients with allergic reaction group was high, and the patients with type I / II allergic reaction had more chemotherapy. Conclusion The increase of chemotherapy and oxaliplatin chemotherapy have intermittent and allergic reactions.