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天麻钩籐饮为中医治疗高血压病常用的一个方剂,临床观察說明其疗效較好。实驗室的观察也說明天麻鈎藤飲在高血压动物有降压作用。为了进一步研究天麻钩藤飲的药理作用,选择了几項指标,观察高血压病人在服用天麻钩藤飲的过程中,这几項指标有无改变。选用的指标包括二氧化碳吸入反应、血清胆硷酯酶活性、尿中17羟类固醇排出量和腎血浆流量。这四項指标分別反映血管运动中枢、植物神經、腎上腺皮层和腎脏的功能状态;而这几項功能状态与高血压病的病因和病理有較密切的关系。Hardgrove等报告高血压病人的二氧化碳吸入反应較健康人为强。文献中曾有报导指出在高血压情况下血清胆硷酯酶活性和17羟类固醇排出量增高。高血压病人的腎血浆流量往往低于健康人。观察高血压病人在天麻钩藤饮治疗前后这四項指标的变化将有助于了解天麻钩藤饮的作用。
Tianma Gouteng Decoction is a commonly used prescription for the treatment of hypertension in traditional Chinese medicine. Clinical observations indicate that the effect is better. Laboratory observations also showed that Tianma Gouteng Decoction has antihypertensive effect in hypertensive animals. In order to further study the pharmacological effects of Tianma Gouteng Decoction, several indicators were selected to observe whether these indicators change during the course of taking Tianma Gouteng Drink. The indicators used included carbon dioxide inhalation, serum cholesterase activity, urinary 17 hydroxysteroid excretion, and renal plasma flow. These four indicators reflect the functional status of vasomotor centers, autonomic nerves, adrenal cortex and kidneys, respectively, and these functional states are closely related to the etiology and pathology of hypertension. Hardgrove et al. reported that the inhaled carbon dioxide in hypertensive patients was stronger than in healthy individuals. There have been reports in the literature that serum cholesterase activity and 17-hydroxysteroid excretion increased in the setting of hypertension. Renal plasma flow in hypertensive patients is often lower than in healthy people. Observing the changes of these four indexes before and after treatment of Tianma Gouteng Decoction in hypertensive patients will help to understand the role of Tianma Gouteng Decoction.