Angew.Chem.Int.Ed.2015,54,638~642三氟甲基(CF3)官能团的引入通常能显著改变母体分子的物理、化学和生物性质,因此含三氟甲基的有机化合物在药物、材料和生物化学等诸多领域被广泛应用.由于自然界中的氟元素绝大多数以无机物的形式存在,如何向有机分子引入三氟甲基便成为一个重要研究命题.目前有机化学家们主要采用直接三氟甲基化法或含三氟甲基的砌块法实现向目标分子中引入三氟甲基.但是这两种方法都必须预先获得含三氟甲基官能团的前体,然后再拼接.中国 Angew.Chem.Int.Ed.2015,54,638-642 The introduction of the trifluoromethyl (CF3) functional group usually significantly changes the physical, chemical and biological properties of the parent molecule and therefore the use of trifluoromethyl-containing organic compounds in pharmaceuticals, materials And biochemistry and other fields are widely used.As most of the fluorine in nature exist in the form of inorganic compounds, how to introduce trifluoromethyl into organic molecules has become an important research topic.At present, organic chemists mainly use direct Trifluoromethyl can be introduced into the target molecule by either the trifluoromethylation method or the trifluoromethyl-containing block method, but both methods must obtain the trifluoromethyl functional group-containing precursors before splicing. China