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目的比较10 d序贯疗法与传统四联疗法根治幽门螺杆菌(Hp)的疗效与安全性。方法选取48例14C尿素呼气试验阳性病例,随机分为两组:治疗组前5 d予奥美拉唑或埃索镁拉唑、阿莫西林,后5 d予奥美拉唑、克拉霉素、替硝唑、枸橼酸铋钾治疗;对照组予奥美拉唑、克拉霉素、替硝唑、枸橼酸铋钾治疗10 d。疗程结束1个月后行14C尿素呼气试验检测。结果治疗组14C尿素呼气试验根除率为92.6%,对照组根除率为95%,两组Hp根除率比较差异无统计学意义(P>0.05)。结论 10 d序贯疗法Hp的根治率较传统四联疗法具有疗效相当,耐受性和依从性好,安全可靠,经济花费减少。
Objective To compare the efficacy and safety of 10-day sequential therapy and traditional quadruple therapy in the treatment of Helicobacter pylori (Hp). Methods 48 cases of 14C urea breath test positive cases were randomly divided into two groups: the treatment group before 5 d to omeprazole or ersollazole, amoxicillin, after 5 d to omeprazole, Tinidazole and bismuth potassium citrate, while the control group was given omeprazole, clarithromycin, tinidazole and bismuth potassium citrate for 10 days. One month after the end of treatment line 14C urea breath test. Results In the treatment group, the eradication rate of 14 C urea breath test was 92.6%, while that of the control group was 95%. There was no significant difference in Hp eradication rate between the two groups (P> 0.05). Conclusions 10-day sequential therapy Hp has a curative effect compared with traditional quadruple therapy, which has good tolerability and compliance, is safe and reliable, and reduces the economic cost.