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目的探讨布拉氏酵母菌联合香砂枳术丸治疗功能性消化不良(FD)的临床疗效。方法 258例FD患者随机分为A组、B组和C组,各86例,A组给予香砂枳术丸一次1袋,一日2次口服;B组给予布拉氏酵母菌散剂1.0g/次,一日2次口服;C组(A组+B组),4周为一疗程。结果 C组临床总有效率均明显优于A组与B组(P<0.01,P<0.05),差异有显著性。3组临床症状积分均比治疗前降低;治疗后C组与A组、B组比较(P均<0.01),差异有显著性。复发率比较:C组明显低于A组、B组(P<0.01,P<0.05),差异有显著性。治疗过程中未见明显不良反应。结论布拉氏酵母菌联合香砂枳术丸可明显提高FD的临床疗效,降低复发率。
Objective To investigate the clinical efficacy of B yeast combined with Xiangsha Zhizhu Pills in the treatment of functional dyspepsia (FD). Methods A total of 258 patients with FD were randomly divided into group A, group B and group C, with 86 cases in each group. Group A received Xiangsha Zhizhu Pills once a day for 2 times a day. Group B received 1.03g / Times, 2 times a day orally; C group (A + B group), 4 weeks for a course of treatment. Results The total clinical effective rate in group C was significantly better than that in group A and group B (P <0.01, P <0.05), the difference was significant. The scores of clinical symptom in 3 groups were all lower than those before treatment. There was significant difference between C group and A group and B group after treatment (P <0.01). Relapse rate comparison: C group was significantly lower than the A group, B group (P <0.01, P <0.05), the difference was significant. No obvious adverse reactions during treatment. Conclusion The combination of Brachyevilla and Xiangsha Zhizhu Pill can significantly improve the clinical efficacy and reduce the recurrence rate of FD.