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目的本文通过100例就诊病例的用药观察,分析适当剂量使用辛伐他汀治疗高脂血症的疗效及安全性。方法按照本院就诊先后顺序,以非药物治疗条件为基础,累计抽取近年来高血脂就诊患者100门病人,采用小剂量辛伐他汀(10mg)每天一次,晚间顿服。以4周、8周为检测周期,检测血总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)的数据变化。结果根据检测结果,用药4周后总有效率为81%;用药8周后总有效率为97%。所有病人无特殊不良反应。结论小剂量国产辛伐他汀(10mg/天)治疗高脂血症,能够达到目标水平,效果显著、持久,药物不良反应少,尤其无肝脏不良反应,并且经济、方便、病人依从性好。
Objective This article through 100 cases of medical treatment observation cases, analysis of the appropriate dose of simvastatin treatment of hyperlipidemia efficacy and safety. Methods According to the order of hospital treatment, based on the non-drug treatment conditions, a total of 100 patients with hyperlipidemia were recruited in recent years. Small doses of simvastatin (10 mg) were given once daily and evening meals. The changes of blood total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) were measured at 4 weeks and 8 weeks. Results According to the test results, the total effective rate was 81% after 4 weeks of treatment; the total effective rate was 97% after 8 weeks of treatment. All patients without special adverse reactions. Conclusion Small doses of domestic simvastatin (10mg / day) for the treatment of hyperlipidemia, can achieve the target level, the effect is significant, lasting, adverse drug reactions, especially no adverse reactions to the liver, and economical, convenient and patient compliance is good.