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目的:了解我院真菌感染临床分布及耐药性变化,以引起临床广泛关注。方法:念珠菌显色培养基鉴定2008年1~6月期间不同标本中分离的真菌,Rosco纸片扩散法作真菌药敏试验,包括氟康唑、二性霉素B、伊曲康唑和氟胞嘧啶四种抗真菌药物。结果:192株临床真菌中,白色假丝酵母菌为主,主要分布于痰和尿标本中,对四种抗真菌药物的敏感率除伊曲康唑外均超过90%以上。结论:深部真菌感染主要由白色假丝酵母菌、热带假丝酵母菌,光滑假丝酵母菌引起,重视真菌的培养鉴定和药敏试验,指导临床合理选择抗真菌药物。
Objective: To understand the clinical distribution of mycosis fungus infection and drug resistance changes in order to cause widespread clinical attention. Methods: Candida chromogenic medium was used to identify the fungi isolated from different samples from January to June in 2008. The Rosco disk diffusion method was used for the fungal susceptibility testing including fluconazole, amphotericin B, itraconazole and Flucytosine four antifungal drugs. Results: Among the 192 clinical fungi, Candida albicans mainly distributed in sputum and urine samples, and the sensitivity to four antifungal drugs exceeded 90% except for itraconazole. Conclusion: The deep fungal infections are mainly caused by Candida albicans, Candida tropicalis and Candida glabrata. The culture identification and drug susceptibility test of fungi are important to guide the clinical selection of antifungal agents.