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目的:调查了解我国体内药物分析领域的药物分布规律,以评价有关药物研究的现状与水平。方法:以我国体内药物分析论著量居前8位的期刊作为文献源,系统查阅16年1582篇体内药物分析论著,运用文献计量学方法,用药物品种数衡量各类药物研究的聚集离散程度、报道频次,反映各类研究的冷热程度,定量研究文献中药物研究的状况。结果:每类药物含品种数>20种,且报道频次构成比>5%的重点类型有9类,报道频次>10次的重点药物共47种;列前3位的重点类型为抗生素、心血管系统药和抗精神失常药,居前3位的重点药物为茶碱、笨妥英钠和庆大霉素;研究的热点依次为方法学、药物动力学、生物利用度和 TDM。结论:从体内药物分析文献定量研究可窥探体内药物分析各类药物研究的聚集与冷热程度;可追踪研究重点类型与重点药物分析的动态。
OBJECTIVE: To investigate the distribution of drugs in the field of drug analysis in China so as to evaluate the current status and level of drug research. Methods: Based on the first eight articles with in vivo pharmacokinetic analysis, the author systematically consulted 1582 articles of in-vivo pharmaceutical analysis in 16 years, and used bibliometrics methods to measure the degree of aggregation of various types of drugs by means of the number of drugs. Report frequency, reflect the degree of hot and cold of various types of research, quantitative research literature on the status of research. Results: There were 20 types of drugs in each category, 9 types of key types with frequency of> 5%, and 47 kinds of key drugs with frequency of> 10. The top three most important types were antibiotics, heart Vascular system drugs and antipsychotic drugs, the top three key drugs for theophylline, stupid sodium and gentamicin; research hot spots followed by methodology, pharmacokinetics, bioavailability and TDM. CONCLUSION: Quantitative study of in vivo drug analysis literature can be used to explore the degree of aggregation and the degree of cold and heat of various drugs in vivo drug analysis; can follow the dynamics of key types and key drug analysis.