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目的了解邯郸市各医院使用的他汀类药物不良反应(ADR)发生情况,为临床合理用药提供依据。方法对邯郸市药品不良反应监测机构上报的2001—2013年他汀类药物不良反应登记资料进行回顾性统计分析。结果 ADR累及多个系统–器官,主要包括肝胆、胃肠、肌肉骨骼及神经系统,其他系统相对少见。严重不良反应以肝损害最常见;不同他汀类ADR有所差异,辛伐他汀主要累及肌肉骨骼、胃肠系统和肝胆系统,阿托伐他汀主要累及肝胆和神经系统,氟伐他汀主要累及胃肠系统。结论目前在临床上应用的他汀类药物在常规剂量范围内均有ADR发生,应规范降脂用药剂量和时限,减少不良反应发生。
Objective To understand the incidence of statin adverse reactions (ADRs) used in hospitals in Handan City and provide the basis for clinical rational drug use. Methods Retrospective statistical analysis of registration data of statin adverse reactions reported by Drug Adverse Drug Reaction Monitoring Institutions in Handan from 2001 to 2013 was conducted. Results ADR involved multiple systems - organs, including hepatobiliary, gastrointestinal, musculoskeletal and nervous system, other systems are relatively rare. Severe adverse reactions to liver damage is most common; different statins ADR vary, simvastatin mainly involving the musculoskeletal, gastrointestinal and hepatobiliary system, atorvastatin mainly affects the hepatobiliary and nervous system, fluvastatin mainly involved in gastrointestinal system. Conclusion At present, statins used clinically have ADR in the range of normal dose, dosage and time limit of lipid-lowering medication should be regulated, and adverse reactions should be reduced.