论文部分内容阅读
热原至今仍然是制剂特别是某些输液和部分生化制品中常见而难以解决的问题,也是我们在代血浆研究过程中需要解决的首要问题。在明胶代血浆的研究中,我们以市售明胶为原料,经0.075N 氢氧化钠处理,能可靠地去除热原,并对有关条件进行了探讨,现报告如下。实验方法与结果一、材料明胶:照相用甲级明胶、粒状。上海炽昌新牛皮胶厂出品。活性炭:医药用,经酸碱及180℃活化处理。石棉除菌板:四川生物制品研究所产品。蔡氏(Seitz)滤器:自制。二、方法与结果1.活性炭吸附法:取明胶9g,加无热原蒸馏水浸泡。溶解后配成6%溶液,调 pH
Pyrogen is still a common and intractable problem in preparation, especially in some infusions and some biochemical products. It is also the most important issue that we need to solve in the generation of plasma research. In the gelatin generation of plasma research, we use commercially available gelatin as raw material, 0.075N sodium hydroxide treatment, can be reliably removed pyrogen, and the conditions were discussed, are as follows. Experimental methods and results First, the material Gelatin: photographic grade gelatin, granular. Shanghai Chi Chang new leather factory production. Activated carbon: medical use, acid and alkali and 180 ℃ activation treatment. Asbestos sterilization board: Institute of Biological Products in Sichuan. Seitz filters: homemade. Second, methods and results 1. Activated carbon adsorption method: Take gelatin 9g, add pyrogen-free distilled water immersion. After dubbed 6% solution, adjust pH