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目的检测良性骨肿瘤、恶性骨肿瘤患者及正常对照组血清中的I型胶原吡啶交联终肽(ICTP)活性,以评价ICTP在良恶性骨肿瘤诊断和鉴别诊断中的价值。方法选取2005~2010年本院骨肿瘤科收治的78例恶性骨肿瘤患者,设为A组,其中49例为原发性恶性骨肿瘤、10例为继发性恶性骨肿瘤、19例为骨转移性肿瘤患者,另选43例良性骨肿瘤患者为B组,同时,设52例同龄正常人为C组,均采用酶免疫测定(EIA)方法测定他们血清中的ICTP活性。结果 B组患者血清ICTP活性为(6.75±3.34)μg/L,C组血清ICTP活性为(4.68±2.91)μg/L,A组患者血清ICTP活性为(14.84±8.49)μg/L,其中,原发性恶性骨肿瘤患者、继发性恶性骨肿瘤、骨转移性肿瘤患者的血清ICTP活性分别为(17.47±10.86)μg/L、(8.02±6.19)μg/L、(8.14±5.45)μg/L.A组中三类患者的血清ICTP活性与B组,C组相比差异均有统计学差异(P<0.05),B组患者与C组相比差异无统计学差异(P>0.05)。而A组中原发性恶性骨肿瘤与继发性恶性骨肿瘤、骨转移性肿瘤组之间的差异也有统计学意义(P<0.05)。结论血清ICTP是反映骨肿瘤骨代谢的一个灵敏而简便的检测指标,并对良恶性骨肿瘤的诊断及鉴别诊断具有重要的临床意义。
Objective To detect the ICTP activity of type I collagen in sera of patients with benign bone tumors, malignant bone tumors and normal controls to evaluate the value of ICTP in the diagnosis and differential diagnosis of benign and malignant bone tumors. Methods Seventy-eight patients with malignant bone tumors admitted to our hospital from 2005 to 2010 were selected as group A. 49 cases were primary malignant bone tumors, 10 cases were secondary malignant tumors and 19 cases were bone In the metastatic tumor group, 43 patients with benign bone tumor were selected as group B. At the same time, 52 normal subjects of the same age were selected as group C, and their serum ICTP activities were measured by enzyme immunoassay (EIA). Results Serum ICTP activity was (6.75 ± 3.34) μg / L in group B, (4.68 ± 2.91) μg / L in group C, and (14.84 ± 8.49) μg / L in group A, The ICTP activities of patients with primary malignant bone tumor, secondary malignant bone tumor and bone metastatic tumor were (17.47 ± 10.86) μg / L, (8.02 ± 6.19) μg / L, (8.14 ± 5.45) μg (P <0.05). There was no significant difference between group B and group C (P> 0.05). There was no significant difference between group B and group C (P> 0.05). However, the difference between primary malignant bone tumor and secondary malignant bone tumor and metastatic bone tumor in group A was also statistically significant (P <0.05). Conclusions Serum ICTP is a sensitive and simple detection index to reflect the bone metabolism of bone tumor and has important clinical significance in the diagnosis and differential diagnosis of benign and malignant bone tumors.