自1978年来溶栓治疗法用于冠状动脉血栓已有很大进展。静脉内给药因需要条件不多,可以争取早期治疗(至少提早1h)。国内已组成协作组进行观察,但地市级医院对开展这项治疗仍有顾虑,现将本人的体会作一介绍。 1 溶栓治疗的目的总的目的是为了减少梗塞急性期的死亡率,但更重要的是保持有效生命。治疗必须达到以下几项要求:①挽救濒临坏死边缘的心肌;②缩小梗塞面积;③保持或恢复心肌功能;④预防血管的再阻塞;⑤减少因溶栓治疗而发生的不良反应。为了达到上述要求,必须使梗塞及早再通,而关键因素是用药的时间及剂量。动物实验提示,若血管持续 Thrombolytic therapy has been used for coronary thrombus since 1978 and great progress has been made. Due to the need for intravenous administration is not much, you can fight for early treatment (at least 1h earlier). Domestic collaboration groups have been formed for observation, but prefecture-level hospitals are still concerned about the implementation of this treatment, and now I will make an introduction to the experience. The purpose of thrombolytic therapy The overall purpose is to reduce the mortality rate of acute stage of infarction, but more importantly, to maintain effective life. Treatment must meet the following requirements: ① to save the edge of the brink of necrosis of the myocardium; ② reduce infarct size; ③ maintain or restore myocardial function; ④ prevent vascular reocclusion; In order to achieve the above requirements, infarction must be reopened early, and the key factor is the time and dose of medication. Animal experiments suggest that if the blood vessels continue