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目的观察桂枝茯苓胶囊联合米非司酮治疗子宫肌瘤的效果。方法选取2010年3月—2012年7月治疗的子宫肌瘤患者80例,随机分为观察组和对照组各40例。两组均给予米非司酮25 mg睡前服用,1次/d;观察组在此基础上口服桂枝茯苓胶囊每次4粒,3次/d。两组均连续治疗3个月。对比两组的疗效,治疗前后计算两组最大肌瘤体积和子宫体积,抽血查黄体生成激素(luteinizing hormone,LH)、雌二醇(estradiol,E)2、卵泡刺激素(follicle-stimulatinghormone,FSH)和孕酮(progesterone,P),观察不良反应。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果总有效率对照组80.0%,观察组95.0%,两组比较差异有统计学意义(P<0.05)。观察组治疗后最大肌瘤体积、子宫体积[(35.51±16.07)、(105.21±26.27)mm3]均小于对照组[(43.41±16.32)、(118.31±29.52)mm3],比较差异均有统计学意义(均P<0.05)。观察组治疗后LH、E2、FSH、P[(10.21±3.26)μg/L、(160.63±43.31)pmol/L、(10.89±4.63)mU/ml、(5.43±1.34)nmol/L]均优于对照组[(13.24±4.63)μg/L、(181.24±44.12)pmol/L、(14.73±4.45)mU/ml、(8.23±1.89)nmol/L],比较差异均有统计学意义(均P<0.05)。对照组腹泻、呕吐4例,皮疹3例;观察组腹泻、恶心2例,皮疹1例。对症处理后不良反应均消失。结论桂枝茯苓胶囊联合米非司酮治疗子宫肌瘤可明显缩小肌瘤体积和子宫体积,改善激素水平,临床效果显著。
Objective To observe the effect of Guizhi Fuling Capsule combined with mifepristone in the treatment of uterine fibroids. Methods Eighty patients with uterine leiomyoma treated from March 2010 to July 2012 were randomly divided into observation group (40 cases) and control group (40 cases). Both groups were given mifepristone 25 mg before bedtime, 1 time / d; on the basis of the observation group, oral Guizhi Fuling capsule 4 times a day, 3 times / d. Both groups were treated for 3 months. The curative effect of the two groups was compared. The maximal fibroid volume and uterine volume were calculated before and after treatment. Luteinizing hormone (LH), estradiol (E) 2, follicle-stimulatinghormone FSH) and progesterone (P) to observe adverse reactions. Measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results The total effective rate was 80.0% in the control group and 95.0% in the observation group, with significant difference between the two groups (P <0.05). The maximum fibroid volume, the uterine volume in the observation group were significantly lower than those in the control group [(35.51 ± 16.07), (105.21 ± 26.27) mm3] (43.41 ± 16.32, 118.31 ± 29.52 mm3, respectively) Significance (all P <0.05). The levels of LH, E2, FSH, P [(10.21 ± 3.26) μg / L, (160.63 ± 43.31) pmol / L and (10.89 ± 4.63) mU / ml and (5.43 ± 1.34) nmol / L] (13.24 ± 4.63) μg / L, (181.24 ± 44.12) pmol / L and (14.73 ± 4.45) mU / ml respectively compared with the control group (8.23 ± 1.89) nmol / L P <0.05). Control group, diarrhea, vomiting in 4 cases, 3 cases of rash; observation group, diarrhea, nausea in 2 cases, 1 case of rash. Symptomatic treatment of adverse reactions were disappeared. Conclusion Guizhi Fuling capsule combined with mifepristone treatment of uterine fibroids can significantly reduce fibroid volume and uterine volume, improve hormone levels, the clinical effect was significant.