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目的通过补充镁、β-胡萝卜素及其联合制剂,探讨其对实验2型糖尿病大鼠糖脂代谢的影响及其作用机制。方法利用链脲佐菌素(STZ)建立2型糖尿病大鼠动物模型,将其随机分为糖尿病模型组、镁组、β-胡萝卜素组及镁+β-胡萝卜素组、正常对照组。实验期8周,检测大鼠血糖(Glu)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)含量,并计算胰岛素抵抗指数(HOMA-IR)。结果8周干预后,镁组、β-胡萝卜素组以及镁+β-胡萝卜素组血糖值分别为(7.57±5.61),(7.85±4.11)和(6.09±3.43),较模型组(13.28±4.11)明显降低(P<0.05);镁+β-胡萝卜素组TG、LDL分别为(1.63±0.64),(0.29±0.08),较模型组(2.65±0.67),(0.45±0.16)明显降低(P<0.05);HDL(11.1±0.31)较模型组(0.81±0.10)明显升高(P<0.05);HOMA-IR与模型组(11.94±2.96)比较,镁组(6.64±4.54)明显降低(P<0.05),镁+β-胡萝卜素组(4.95±3.36)明显降低(P<0.01)。结论镁可以明显降低糖尿病大鼠的血糖、改善胰岛素抵抗;β-胡萝卜素可以明显降低血糖;镁和β-胡萝卜素联合补充可以明显改善糖脂代谢、减轻胰岛素抵抗。
Objective To investigate the effect of magnesium and β-carotene and their combination on the glucose and lipid metabolism in experimental type 2 diabetic rats and its mechanism. Methods Animal models of type 2 diabetic rats were established by streptozotocin (STZ) and were randomly divided into diabetic model group, magnesium group, β-carotene group, magnesium + β-carotene group and normal control group. During the experimental period of 8 weeks, the levels of Glu, TG, HDL and LDL in rats were measured and the insulin resistance index (HOMA-IR) was calculated. Results After 8 weeks’ intervention, the blood glucose of magnesium group, β-carotene group and magnesium + β-carotene group were (7.57 ± 5.61), (7.85 ± 4.11) and (6.09 ± 3.43) (1.63 ± 0.64) and (0.29 ± 0.08) respectively in magnesium + β-carotene group compared with model group (2.65 ± 0.67) and (0.45 ± 0.16) (P <0.05); HDL (11.1 ± 0.31) was significantly higher than that of model group (0.81 ± 0.10) (P <0.05); Compared with model group (11.94 ± 2.96), HOMA- (P <0.05), while magnesium + β-carotene group (4.95 ± 3.36) decreased significantly (P <0.01). Conclusion Magnesium can significantly reduce the blood glucose in diabetic rats, improve insulin resistance; β-carotene can significantly lower blood sugar; magnesium and β-carotene combined can significantly improve glucose and lipid metabolism, reduce insulin resistance.