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目的探讨雷公藤甲素对异种神经移植后神经再生的影响。方法将日本大耳兔的神经移植于Ｗｉｓｔａｒ大鼠坐骨神经后，宿主服用雷公藤甲素。结果大鼠存活４、８、１２、１６、２４周，可见再生神经纤维长入移植神经并向远段坐骨神经生长。移植神经和远段神经内的再生神经纤维中有髓纤维和无髓纤维兼有之，大部分再生神经纤维聚集成束。术后１２周的腓肠肌ＡＣｈＥ呈阳性，并可见再生神经纤维与运动终板相连。１２周以后的爪部皮下出现再生神经束，真皮层出现游离神经末梢。未服用雷公藤甲素的对照组因免疫排斥反应而神经不能再生。结论雷公藤甲素在异种神经移植中具有免疫抑制作用
Objective To investigate the effects of triptolide on nerve regeneration after xenogeneic nerve transplantation. Methods After the nerve of Japanese rabbit was transplanted into Wistar rat sciatic nerve, the host took triptolide. RESULTS: Rats survived for 4, 8, 12, 16 and 24 weeks. Regenerated nerve fibers grew into the transplanted nerve and grew to the distal sciatic nerve. Both the transplanted nerves and the regenerated nerve fibers in the distal nerves have both myelinated and unmyelinated fibers, and most of the regenerated nerve fibers aggregate into bundles. AChE was positive in gastrocnemius muscle 12 weeks after surgery, and regenerated nerve fibers were connected to the motor endplate. After 12 weeks, regenerating nerve bundles appeared subcutaneously in the paw, and free nerve endings appeared in the dermis. The control group not taking triptolide was unable to regenerate nerves due to immune rejection. Conclusion Triptolide has immunosuppressive effect in xenotransplantation