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目的 研究妊娠期口服葡萄糖耐量试验(oral glucose tolerance test, OGTT)三次取血诊断妊娠期糖尿病(gestational diabetes mellitus, GDM)的可行性。 方法 对404例50 g葡萄糖负荷试验阳性的孕妇行 OGTT 检查。 结果 以美国糖尿病协会(American Diabetes Association,ADA)标准诊断 GDM者 111 例,葡萄糖耐量受损(impaired glucose tolerance test, IGT)者 72 例,OGTT正常者221例;若不计服糖后3 h血糖值,则诊断GDM者106例,IGT者71例,漏诊率分别为4.5%和1.4%。6 例漏诊孕妇与 OGTT正常的 50 g GCT阳性的 221 例孕妇相比,其妊高征、巨大儿、大于胎龄儿和Apgar评分≤3 分的发生率差异无统计学意义(16.6%和 8.1%、16.6%和 6.3%、50.1%和24.4%、0和0.9%,P均>0.05)。 结论 OGTT三次取血操作次数少、漏诊率低,临床上可作为GDM的诊断标准。
Objective To study the feasibility of gestational diabetes mellitus (gestational diabetes mellitus (GDM)) three times during pregnancy oral glucose tolerance test (OGTT). Methods OGTT was performed on 404 pregnant women with 50 g glucose load test. Results There were 111 cases of GDM diagnosed by American Diabetes Association (ADA), 72 cases of impaired glucose tolerance test (IGT) and 221 cases of normal OGTT. , Then the diagnosis of GDM in 106 cases, 71 cases of IGT, misdiagnosis rates were 4.5% and 1.4%. There was no significant difference in the incidence of PIH, macrosomia, gestational age and Apgar score ≤3 among 6 pregnant women with missed diagnosis of OGTT and 221 normal pregnancies with 50 g GCT (16.6% vs 8.1 %, 16.6% and 6.3%, 50.1% and 24.4%, 0 and 0.9% respectively, P> 0.05). Conclusion OGTT three times less bleeding operation, missed diagnosis rate, clinical diagnosis of GDM can be used as a standard.