[目的]观察柴胡舒肝散联合西药四联疗法治疗老年消化性溃疡的疗效及复发率,分析对患者血清表皮生长因子与转化生成因子表达水平的影响。[方法]以本院2013年1月~2015年1月收治的68例老年消化性溃疡患者作为本次研究对象,将全部患者随机均分为对照组与观察组,对照组给予西药四联疗法,观察组在对照组的基础上联合柴胡舒肝散随证加减治疗,治疗结束后评估2组临床疗效、统计幽门螺杆菌转阴率及不良反应发生率;统计2组患者治疗前、后血清表皮生长因子、转化生长因子的表达水平;以溃疡内镜分期评估2组患者溃疡面愈合情况,评估2组患者再生黏膜细胞成熟度,将2组评估数据进行对比分析。[结果]观察组临床治愈率为61.76%,总有效率为97.06%;对照组临床治愈率为29.41%,总有效率为82.35%;观察组临床疗效显著优于对照组,P<0.01。治疗结束时观察组Hp转阴率为91.18%,随访12个月观察组复发率为8.82%;对照组Hp转阴率为67.65%,复发率为29.41%;观察组Hp转阴率与复发率均优于对照组,P<0.05。治疗后2组EGF、TGF-α均有升高,组内比较差异有统计学意义,P<0.01;治疗后观察组EGF、TGF-α均显著高于对照组,P<0.01。观察组Sc期22(64.71%)例,对照组Sc期12(35.29%)例,观察组溃疡面愈合程度显著优于对照组,P<0.01。观察组黏膜组织成熟度优良率为94.12%,对照组黏膜组织成熟度优良率为76.47%,观察组黏膜组织成熟度显著优于对照组,P<0.05。[结论]柴胡舒肝散联合西药四联疗法治疗老年消化性溃疡疗效确切、不易复发且用药安全,可有效提高患者血清中表皮生长因子与转化生长因子的表达水平,促进黏膜再生提升溃疡面愈合程度,值得临床广泛应用。 [Objective] To observe the therapeutic effect and recurrence rate of Chaihu Shugan Powder combined with western medicine quadruple therapy on senile peptic ulcer, and analyze the influence on the expression level of serum epidermal growth factor and transforming growth factor. [Methods] A total of 68 elderly patients with peptic ulcer admitted to our hospital from January 2013 to January 2015 were randomly divided into control group and observation group. All patients in control group were given western medicine quadruple therapy , The observation group on the basis of the control group combined with Bupleurum Shugan powder card plus treatment, after treatment, the clinical efficacy of two groups were evaluated, the incidence of Helicobacter pylori negative rate and adverse reactions were statistically analyzed; before and after treatment, The serum level of epidermal growth factor (EGFR) and transforming growth factor (TGF-β1) were measured. The ulcer surface healing was evaluated by endoscopy in two groups. The maturation of regenerated mucosa cells in two groups was evaluated. [Results] The clinical cure rate was 61.76% in the observation group and the total effective rate was 97.06%. The clinical cure rate in the control group was 29.41% and the total effective rate was 82.35%. The clinical curative effect in the observation group was significantly better than that in the control group (P <0.01). At the end of treatment, the Hp negative conversion rate was 91.18% in the observation group and 8.82% in the 12-month follow-up group. The negative conversion rate of Hp in the control group was 67.65% and the recurrence rate was 29.41% All better than the control group, P <0.05. The levels of EGF and TGF-α in the two groups increased after treatment, the differences were statistically significant (P <0.01). After treatment, the levels of EGF and TGF-α in the observation group were significantly higher than those in the control group (P <0.01). In the observation group, 22 (64.71%) cases were in the Sc stage and 12 (35.29%) cases in the control group were Sc stage. The degree of ulcer healing in the observation group was significantly better than that in the control group (P <0.01). The excellent and good rate of mucosal maturation in the observation group was 94.12%. The excellent and good rate of mucosal maturation in the control group was 76.47%. The mucosal maturity of the observation group was significantly better than that of the control group (P <0.05). [Conclusion] Chaihu Shugan Powder combined with western medicine quadruple therapy is effective in treating elderly patients with peptic ulcer. It is difficult to relapse and safe to use. It can effectively improve the expression of epidermal growth factor and transforming growth factor in serum and promote mucosal regeneration to promote ulcer surface The degree of healing, it is widely used in clinical.