论文部分内容阅读
孕酮是在神经系统中合成的神经活性甾体,通过对神经系统功能的影响,发挥神经营养和保护作用。孕酮在各种脑损伤后的神经保护作用日益受到关注,流行病学调查、动物实验以及临床研究结果显示:孕酮可减轻脑损伤后出现的脑水肿,减小脑梗死体积,减轻实验性脑缺血损伤;孕酮能够减轻脂质过氧化反应、减少自由基产生、稳定膜结构、保护血脑屏障;孕酮还具有调节一氧化氮生成、抗神经兴奋性毒性、抗调亡、调节炎症反应和神经营养等作用。
Progesterone is a neuro-active steroid that is synthesized in the nervous system and exerts neuronal nutrition and protection through its effects on nervous system function. The neuroprotective effects of progesterone after various brain injuries are receiving increasing attention. Epidemiological investigation, animal experiments and clinical studies have shown that progesterone can reduce brain edema, reduce the volume of cerebral infarction and reduce the experimental Progesterone can reduce lipid peroxidation, reduce free radical production, stabilize the membrane structure, protect the blood-brain barrier; progesterone also has a regulation of nitric oxide production, anti-neural excitotoxicity, anti-apoptosis, regulation Inflammatory response and neurotrophic effects.