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本文报告10例因骨髓纤维化、再生障碍性贫血、阵发性睡眠性血红蛋白尿及“多毛细胞”性白血病(“Baiy cell”leukemia)所致的骨髓衰竭,经雄激素和/或醣皮质激素治疗无效后,试用5β-雄酮(Etiocholanolone,和强的松龙联合治疗的情况。5β-雄酮,是睾丸酮的非雄性代谢产物。能刺激体外的生血细胞的前体进入细胞循环和增加血晶质的合成,在体内能增加红细胞Fe的结合。应用强的松龙可减少单用5β-雄酮的炎症反应。每天肌注5β-雄酮0.3毫克/公斤,20毫克/毫升)和醋酸强的松龙(0.4毫克/公斤,50毫克/毫升),共2～4周,以后,隔日1次,以
This article reports 10 cases of bone marrow failure due to myelofibrosis, aplastic anemia, paroxysmal nocturnal hemoglobinuria, and “Baiy cell” leukemia, which is treated with androgen and / or glucocorticoid After treatment is ineffective, a combination of Etiocholanolone and prednisolone is tested.5β-Androsterone, a non-male metabolite of testosterone, stimulates precursors of hematopoietic cells in vitro to enter the cell cycle and increase blood Crystallization of the synthesis can increase the binding of erythrocyte Fe in the body.Use of prednisolone can reduce the inflammatory response of 5β-androsone alone.Mineral injection of 5β-androsterone 0.3 mg / kg intramuscularly, 20 mg / ml) and acetic acid Prednisolone (0.4 mg / kg, 50 mg / ml) for a total of 2 to 4 weeks, thereafter, every other day to