目的探讨美常安联合乳果糖治疗老年肠易激综合征便秘型的疗效和安全性。方法收集79例老年肠易激综合征便秘型患者,根据治疗药物分为3组:A组单用美常安组26例;B组单用乳果糖组26例。C组乳果糖联合美常安组27例,疗程均为4周。观察患者服药后起效时间、每天排便次数、排便是否费力以及粪便性状,同时观察腹痛、腹胀、食欲不振等症状的缓解率。结果服药后24h起效者联合用药组为37.0%(10/27),美常安组为15.4%(4/26),乳果糖组为23.1%(6/26),联合用药组明显高于乳果糖组(P<0.05)和美常安组(P<0.05);服药4周后A、B、C组总有效率分别为:46.2%(12/26)、50.0%(13/26)、85.1%(23/27),总有效率联合用药组明显高于乳果糖组(P<0.05)和美常安组(P<0.05),同时美常安组与乳果糖组间差异无统计学意义(P>0.05)。治疗2周后A、B、C组对腹痛的缓解率分别为:33.3%、31.3%、65.0%,对腹胀缓解率分别为:45.5%、40.0%、88.0%。同时各组均无严重不良反应发生。结论美常安联合乳果糖治疗老年肠易激综合征便秘型疗效优于单用乳果糖及美常安,同时起效快,症状改善好,不良反应少,因此是一种安全、有效的治疗方法。 Objective To investigate the efficacy and safety of the combination of Changsheng’an and lactulose in treating constipation of elderly irritable bowel syndrome. Methods A total of 79 elderly patients with constipation-induced irritable bowel syndrome were collected and divided into 3 groups according to the therapeutic drugs: 26 patients in group A and 26 patients in group B alone. C group lactulose combined with the United States Changan group of 27 cases, treatment were 4 weeks. Observe the onset time after taking the drug, defecation times per day, stool effort and stool traits, while observing abdominal pain, bloating, loss of appetite and other symptoms of remission. Results In the combined group, 37.0% (10/27) of the combination group and 15.4% (4/26) in the group of the normal American and American and the control group were 23.1% (6/26) in the lactulose group and the combined group was significantly higher than that in the combined group The total effective rates of A, B and C groups were 46.2% (12/26), 50.0% (13/26), 85.1% (P <0.05) (P <0.05). The total effective rate in combination group was significantly higher than that in lactulose group (P <0.05) and that in normal group (P <0.05), and there was no significant difference between the two groups ). After 2 weeks of treatment, the remission rates of abdominal pain in groups A, B and C were 33.3%, 31.3% and 65.0%, respectively. The remission rate to abdominal distension was 45.5%, 40.0% and 88.0% respectively. At the same time, no serious adverse reactions occurred in all groups. Conclusions Mei Changan combined with lactulose treatment of elderly irritable bowel syndrome constipation efficacy is superior to lactulose alone and the United States regular security, and rapid onset, symptoms improved, fewer adverse reactions, it is a safe and effective treatment.