探讨思密达在肿瘤化疗所致消化道反应中的应用价值。方法 :对54例接受顺铂联合方案化疗的恶性肿瘤病人进行止吐治疗观察。于化疗第一周期或第二周期使用思密达加枢复宁止吐 ,同一病人于另一周期只用枢复宁作自身对照 ,思密达每次3 0g,每日3次于化疗前一天开始连服5d。结果 :两种止吐方法对化疗后24h内急性恶心呕吐有效率无差异 ,化疗后2～5d ,观察组恶心和呕吐有效率均高于对照组 (P<0 01)。观察组恶心呕吐持续时间短于对照组 ,两组平均恶心持续时间分别为53 37h和94 27h(P<0 01) ,平均呕吐持续时间为30 40h和50 50h (P<0 01)。结论 :思密达与5 HT3 受体拮抗剂联合应用对控制顺铂化疗所致迟发性恶心呕吐有较好效果 To explore the value of Smecta in the digestive tract reaction caused by chemotherapy. METHODS: Anti-emetic treatment was performed on 54 patients with malignant tumor who received cisplatin combined chemotherapy. The use of Smecta Plus Fafin and Antiemetic in the first cycle or the second cycle of chemotherapy, the same patient only used shufuning as its own control in another cycle, Smecta 30g each time, three times daily before chemotherapy One day even started serving 5d. Results: There was no difference in the effective rate of acute nausea and vomiting within 24 hours after chemotherapy between the two antiemetic methods. The effective rate of nausea and vomiting was higher in the observation group than in the control group 2 to 5 days after chemotherapy (P<0.01). The duration of nausea and vomiting in the observation group was shorter than that in the control group. The average duration of nausea in the two groups was 53 37 h and 94 27 h respectively (P<0 01), and the average duration of vomiting was 30 40 h and 50 50 h (P<0 01). Conclusion : Combination of Smecta and 5 HT3 receptor antagonists has a good effect on controlling delayed nausea and vomiting induced by cisplatin chemotherapy