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本实验选用 4 0只雄性ICR封闭群小鼠 ,随机分为 4组 :对照组、低氧暴露组、运动组、运动 +低氧组 ,每组 10只。 4周训练结束后 ,取心、脑、完整的腓肠肌 ,测试各组织MDA含量及SOD活性。实验结果提示 :(1)间歇性低氧暴露提高了心肌组织的SOD水平 ,同时MDA水平下降 ,表明心肌抗氧化能力提高 ,有利于在长时间运动中保持正常供血功能。 (2 )间歇性低氧暴露提高骨骼肌组织SOD活性和降低MDA含量 ,表明间歇性低氧暴露可有效提高骨骼肌抗氧化能力。 (3)间歇性低氧暴露可提高脑组织对过氧化脂质的清除能力和SOD活性 ,对于延缓中枢疲劳有意义。
In this experiment, 40 male ICR closed mice were randomly divided into 4 groups: control group, hypoxic exposure group, exercise group, exercise + hypoxia group, 10 in each group. After 4 weeks of training, the heart, brain and intact gastrocnemius muscle were taken and MDA content and SOD activity in each tissue were tested. The results suggest that: (1) Intermittent hypoxic exposure increased myocardial SOD levels, while MDA levels decreased, indicating that myocardial antioxidant capacity increased, is conducive to maintaining normal blood supply during long periods of exercise. (2) Intermittent hypoxic exposure increased SOD activity and decreased MDA content in skeletal muscle tissue, indicating that intermittent hypoxia exposure can effectively improve skeletal muscle antioxidant capacity. (3) Intermittent hypoxic exposure increased brain tissue lipid peroxidation and SOD activity, which is meaningful for delaying central fatigue.