天疱疮是一种罕见的慢性上皮内大疱性损害,有致死性。多为皮肤、口腔共患。口腔损害主要发生在软腭,其侵犯食管不常见。本文对口腔天疱疮侵犯食管的临床意义进行了探讨。 材料和方法 8例口腔天疱疮患者,3例为新诊断者,3例为复发者,2例为仅有很少口腔损害的临床症状缓解者。其中5例主诉吞咽困难和吞咽疼痛,3例无症状。对患者进行上消化道胃肠内窥镜、间接免疫荧光、直接免疫荧光检查,并对损害进行活体组织检查和脱落细胞检查。 Pemphigus is a rare chronic intraepithelial lesion that is fatal. Mostly skin, oral co-suffering. Oral damage occurs mainly in the soft palate, its invasion of the esophagus is not common. This article discusses the clinical significance of oral pemphigus invasion of the esophagus. MATERIALS AND METHODS Eight patients with pemphigus pemphigus, three newly diagnosed, three relapsed, and two as clinical remission with only minimal oral lesions. Five of them complained of dysphagia and swallowing pain, and three were asymptomatic. Patients were enrolled in upper gastrointestinal endoscopy, indirect immunofluorescence, direct immunofluorescence, and biopsy and exfoliated cytology for lesions.