目的了解我院婴幼儿眼疾的细菌分布及耐药情况,为临床合理用药提供依据。方法取我院眼科门诊眼疾患儿眼分泌物标本进行细菌培养及药敏试验,对结果进行回顾性分析。结果 1505份标本中,无菌生长149例,占9.9%,有正常菌群生长为840例,占55.8%,有致病菌生长516例,占34.3%。检出致病菌株549株,其中革兰阴性菌278株,占50.6%,以流感嗜血杆菌及肠杆菌为主,两者均对氨苄西林耐药率最高;革兰阳性菌251株,分离率为45.7%,以金黄色葡萄球菌及肺炎链球菌为主,金黄色葡萄球菌对青霉素耐药率最高,肺炎链球菌对红霉素及克林霉素耐药率最高;20株真菌。结论我院流感嗜血杆菌、金黄色葡萄球菌、肺炎链球菌为婴幼儿眼疾主要致病菌,临床应根据眼分泌物培养结果合理选用抗菌药物,避免盲目用药,确保患儿合理、安全、有效用药。 Objective To understand the bacterial distribution and drug resistance of infantile eye diseases in our hospital and provide the basis for clinical rational drug use. Methods The ophthalmology outpatient eye ophthalmological specimens of our hospital for bacterial culture and drug sensitivity test, the results were retrospectively analyzed. Results Of the 1505 specimens, 149 were aseptically grown, accounting for 9.9%. There were 840 cases of normal flora, accounting for 55.8%. There were 516 cases of pathogenic bacteria, accounting for 34.3%. 549 strains of pathogens were detected, of which 278 were Gram-negative bacteria, accounting for 50.6%, mainly Haemophilus influenzae and Enterobacteriaceae, the highest rate of ampicillin resistance; 251 gram-positive bacteria, isolated The rate was 45.7%, Staphylococcus aureus and Streptococcus pneumoniae, Staphylococcus aureus the highest rate of penicillin, Streptococcus pneumoniae erythromycin and clindamycin highest rate of resistance; 20 strains of fungi. Conclusion Our hospital Haemophilus influenzae, Staphylococcus aureus, Streptococcus pneumoniae are the main pathogens of infantile eye diseases. According to the results of ophthalmic secretions, the rational use of antimicrobial agents should be avoided to avoid blind medication, to ensure that the children are reasonable, safe and effective Medication.