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目的探讨感染性腹泻患儿在不同程度、不同阶段时内皮素(ET)、D-二聚体(D-D)的变化。方法选择2011年11月—2013年10月玉林市妇幼保健院住院的腹泻患儿,轻型、中型、重型各20例作为观察组,健康婴幼儿20例作为对照组。观察组在治疗前后全部抽血检测ET、D-D。结果治疗前各组间ET、D-D存在统计学差异,腹泻程度越重,ET、D-D值越高,差异有统计学意义(P<0.01),其中以重型腹泻组明显。重型腹泻组治疗后ET、D-D显著下降,与治疗前相比,差异有统计学意义(P<0.01)。ET与D-D间呈正相关(r=0.51,P<0.01)。结论重型腹泻血浆ET、D-D可作为判断病情的指标,对指导治疗具有重要的参考价值。
Objective To investigate the changes of endothelin (ET) and D-dimer (D-D) in children with infectious diarrhea at different stages and stages. Methods From November 2011 to October 2013, 20 children with diarrhea who were hospitalized in Yulin Maternal and Child Health Hospital were selected as the observation group and 20 healthy infants as the control group. Observation group before and after treatment all blood tests ET, D-D. Results There were significant differences in ET and D-D among the groups before treatment. The more serious the diarrhea, the higher the ET and D-D, the difference was statistically significant (P <0.01), especially in severe diarrhea group. The levels of ET and D-D in severe diarrhea group decreased significantly compared with before treatment (P <0.01). There was a positive correlation between ET and D-D (r = 0.51, P <0.01). Conclusion Serum ET, D-D in patients with severe diarrhea may be used as an index to judge the condition, which is of great reference value for guiding treatment.