论文部分内容阅读
目的将阿托伐他汀应用于原发性高血压患者,观察其对血压和左心室肥厚的影响。方法选择120例原发性高血压患者随机分为对照组和观察组各60例。两组均给予氨氯地平5 mg/d,观察组加服阿托伐他汀20 mg/d治疗8周。同时测量两组治疗前后血压及左心室重量指数(LVM I)变化。结果与对照组相比,观察组收缩压、舒张压、脉压、左心室重量指数均显著降低(P<0.05)。结论阿托伐他汀可显著降低原发性高血压患者的血压、缩小脉压差,使降压更平稳,且能逆转左室肥厚。
Objective To evaluate the effects of atorvastatin on blood pressure and left ventricular hypertrophy in patients with essential hypertension. Methods 120 cases of essential hypertension were randomly divided into control group and observation group of 60 cases. Both groups were given amlodipine 5 mg / d, the observation group plus atorvastatin 20 mg / d for 8 weeks. The changes of blood pressure and left ventricular mass index (LVM I) before and after treatment were also measured. Results Compared with the control group, systolic blood pressure, diastolic blood pressure, pulse pressure and left ventricular mass index were significantly decreased (P <0.05). Conclusions Atorvastatin can significantly reduce the blood pressure in patients with essential hypertension, reduce pulse pressure, make blood pressure more stable and can reverse left ventricular hypertrophy.