论文部分内容阅读
研究有氧运动及其合用人参茎叶皂苷（Ｇｉｎ）对饮食性高脂血症小鼠脂质代谢的影响。方法：通过喂养高胆固醇饲料２０天建立高脂血症模型，以无负重游泳作为有氧运动方式，观察有氧运动及其合用Ｇｉｎ时对高脂状态下小鼠的影响。结果：（１）高胆固醇饲料喂养２０天，小鼠血清ＴＣ，ＭＤＡ升高，ＨＤＬ－ｃ和ＳＯＤ降低，高脂血症模型建造成功，肝重量增加，有脂肪肝出现，胸腺重量减轻．（２）有氧运动降低ＴＣ，升高ＭＤＡ和ＨＤＬ－Ｃ，肝重量不减轻，脂肪肝存在．（３）有氧运动合用Ｇｉｎ时， ＴＣ， ＴＧ和 ＭＤＡ均降低（Ｐ＜ ０．０５）， ＨＤＬ－ｃ和ＳＯＤ显著升高（Ｐ＜０．０１），肝重量减轻和胸腺重量接近正常，脂肪肝消失．结论：单纯有氧运动可在一定程度上降低血脂，但不能很好调节脂质代谢，当有氧运动合用Ｇｉｎ时，其降脂调脂和抗氧化作用才更明显，并可能有一定的减慢机体衰老过程的作用。
To study the effects of aerobic exercise and its combined ginsenosides (Gin) on lipid metabolism in mice with diet-induced hyperlipidemia. Methods: Hyperlipidemia model was established by feeding high cholesterol diet for 20 days. The swimming without load was taken as aerobic exercise mode to observe the effect of aerobic exercise and Gin combined with high fat diet on mice. Results: (1) After fed with high cholesterol diet for 20 days, serum TC, MDA, HDL-c and SOD in mice were reduced. Hyperlipidemia model was successfully established, liver weight increased, fatty liver appeared, and thymus weight decreased. (2) aerobic exercise to reduce TC, increased MDA and HDL-C, liver weight does not reduce the presence of fatty liver. (3) Aerobic exercise combined with Gin decreased TC, TG and MDA (P <0.05), HDL-c and SOD increased significantly (P <0.01), liver weight loss and thymus weight approached normal, Fatty liver disappears. Conclusion: Aerobic exercise alone can reduce blood lipids to a certain extent, but not lipid metabolism. When combined with aerobic exercise, the lipid-lowering, lipid-lowering and anti-oxidative effects of Gin are more obvious and may be reduced to a certain extent Slow body aging process.