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目的研究足月妊娠妇女血清一氧化氮(NO)含量与胎盘功能的关系。方法采用Griess方法测定30例胎盘功能不全足月初孕妇外周血中NO的稳定代谢产物亚硝酸基/硝酸基的含量,以30例胎盘功能正常的孕妇作对照,同时测定胎盘重量和新生儿体重。结果⑴实验组和对照组血清NO含量分别为76.86±29.67μmol/L和1190.16±25.93μmol/L,两组比较有极显著性差异(P<0.01);⑵实验组与对照组的胎盘重量及新生儿体重分别为473.3±31.4g、533.3±37.9g和3094.5±175.6g、3336.7±251.9g,两组比较有极显著性差异(P<0.01),且胎盘重量及新生儿体重与NO含量呈明显正相关。结论足月妊娠妇女NO含量与含量与胎盘功能密切相关,与胎血盘、胎儿发育呈正相关。
Objective To study the relationship between serum levels of nitric oxide (NO) and placental function in term pregnant women. Methods Griess method was used to determine nitrite / nitric oxide content of NO in peripheral blood of 30 pregnant women with placental dysfunction at the beginning of term. The placental weight and neonatal body weight were determined simultaneously in 30 pregnant women with normal placental function. Results (1) Serum NO levels in experimental group and control group were 76.86 ± 29.67μmol / L and 1190.16 ± 25.93μmol / L, respectively, with significant difference (P <0.01). (2) The placental weight and The body weight of newborns were 473.3 ± 31.4g, 533.3 ± 37.9g and 3094.5 ± 175.6g, 3336.7 ± 251.9g, respectively. There was significant difference between the two groups (P <0.01). The weight of placenta and body weight and NO content Obviously positive correlation. Conclusion The content and content of NO in full-term pregnant women are closely related to the function of placenta, and have positive correlation with fetal blood flow and fetal development.