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目的:探讨大黄芒硝外敷结合抗生素治疗盆腔炎性肿块的临床疗效。方法:以2014年9月—2015年3月期间我院收治的68例盆腔炎性肿块患者为研究对象,将其随机分为对照组(34例)和实验组(34例)。两组均采用左氧氟沙星0.5 g 1次/d+甲硝唑0.5 g 1次/8 h静脉滴注治疗,临床症状改善后改口服持续至少14 d;实验组在此基础上加用大黄芒硝袋敷下腹,1次/d,经期停药,15 d为1个疗程。观察两组临床治疗效果,统计停药两个月后两组复发率,记录治疗前后两组患者中医症候总积分的改善情况,B超测定治疗后两组盆腔炎性肿块体积的变化。结果:实验组总有效率(97.06%)明显高于对照组(79.41%),差异具有统计学意义(P=0.027);实验组患者复发率为2.94%,对照组复发率为11.76%,差异不具有统计学差异(P=0.178);两组患者治疗过程中均无明显不良反应;实验组治疗后中医症候总积分为(10.03±6.37)分,对照组为(20.98±3.75)分,两组对比差异有统计学意义(P=0.000);实验组治疗后盆腔炎性肿块体积缩小至(5.21±4.98)cm~2,对照组为(15.49±6.83)cm~2,两组盆腔炎性肿块体积经统计学检验差异有统计学意义(P=0.000)。结论:大黄芒硝腹部外敷联合抗生素治疗盆腔炎性肿块临床疗效显著,治愈率高,具有重要的临床研究价值。
Objective: To investigate the clinical efficacy of rhubarb - mirabilite topical application of antibiotics in the treatment of pelvic inflammatory mass. Methods: Sixty-eight patients with pelvic inflammatory masses admitted from September 2014 to March 2015 in our hospital were randomly divided into control group (34 cases) and experimental group (34 cases). The two groups were treated with levofloxacin 0.5 g 1 / d + metronidazole 0.5 g 1/8 h intravenous infusion, the clinical symptoms improved after oral administration continued for at least 14 d; the experimental group on this basis with Rhubarb mirabilite plus the lower abdomen , 1 / d, menstrual withdrawal, 15 d for a course of treatment. The clinical efficacy of the two groups was observed. The relapse rate of the two groups was recorded after two months of discontinuation. The improvement of the TCM symptom score was recorded before and after treatment. The volume of pelvic inflammatory mass in the two groups was measured by B-ultrasound. Results: The total effective rate (97.06%) in the experimental group was significantly higher than that in the control group (79.41%), the difference was statistically significant (P = 0.027). The recurrence rate was 2.94% in the experimental group and 11.76% in the control group, (P = 0.178). There was no significant adverse reaction in both groups during the course of treatment. The total scores of TCM syndromes in the experimental group were (10.03 ± 6.37) and in the control group (20.98 ± 3.75) (P = 0.000). The volume of pelvic inflammatory mass in experimental group shrank to (5.21 ± 4.98) cm ~ (-2) and that in control group was (15.49 ± 6.83) cm ~ The volume of the tumor was statistically significant difference (P = 0.000). Conclusion: Radix pilosula extracorporeal topical application of antibiotics in the treatment of pelvic inflammatory mass has significant curative effect and high cure rate, which has important clinical research value.