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目的探讨激活素A(activin A,ACTA)在估价慢性乙型病毒性肝炎程度中的作用。方法采用酶联免疫(ELISA)法测定118例患者血清ACTA含量。采用放射免疫(RIA)法测定118例患者血清透明质酸(HA)、IV型胶原(CIV)、层黏连蛋白(LN)水平。结果118例慢性乙肝轻、中、重度及肝硬化患者血清ACTA、HA、CIV、LN均高于对照组,以上指标水平按轻、中、重度及肝硬化次序递增,并以肝硬化组为最高。除轻、中度级LN无显著差异外,其他各组间差异显著(P<0.01)。ACTA与HA、CIV、LN水平呈明显正相关(r=0.6188,P<0.01;r=0.5741,P<0.01;r=0.3336,P<0.05)。结论ACTA能较好地反映慢性肝病纤维化的进展程度,可作为临床评估慢性肝病病变程度和疗效的良好指标,亦可作为肝纤维化的诊断指标。
Objective To investigate the role of activin A (ACTA) in the evaluation of the degree of chronic hepatitis B virus. Methods Serum ACTA levels of 118 patients were determined by enzyme-linked immunosorbent assay (ELISA). The levels of serum hyaluronic acid (HA), type IV collagen (CIV) and laminin (LN) in 118 patients were determined by radioimmunoassay (RIA). Results The serum levels of ACTA, HA, CIV and LN in 118 chronic hepatitis B patients with mild, moderate, severe and cirrhosis were significantly higher than those in the control group. The above indexes were increased in order of light, moderate, severe and cirrhosis, and were highest in cirrhosis . Except mild and moderate grade LN, no significant difference was found between the other groups (P <0.01). ACTA and HA, CIV, LN levels were positively correlated (r = 0.6188, P <0.01; r = 0.5741, P <0.01; r = 0.3336, P <0.05). Conclusion ACTA can better reflect the degree of progression of chronic liver fibrosis, which can be used as a good indicator to evaluate the severity and curative effect of chronic liver disease. It can also be used as a diagnostic indicator of liver fibrosis.